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TUMOR SUPPRESSOR PROTEIN P53
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DeCS
Descriptor
English
:
Tumor Suppressor Protein p53
Descriptor
Spanish
:
Proteína p53 Supresora de Tumor
Descriptor
Portuguese
:
Proteína Supressora de Tumor p53
Synonyms
English
:
p53 Tumor Suppressor Protein
Tree Number:
D12.776.260.820
D12.776.624.776.775
D12.776.660.825
D12.776.744.845
Definition
English
:
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to
control
CELL PROLIFERATION
and
APOPTOSIS
. A mutant or absent p53 protein has been found in
LEUKEMIA
;
OSTEOSARCOMA
;
LUNG
CANCER; and COLORECTAL CANCER.
History Note
English
:
2005(1991);
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
29089
Unique Identifier:
D016159
Occurrence in VHL
:
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